The standard view, the vesicle theory of protein secretion, envisions proteins being carried within and out of cells en masse in membrane-bound sacs or vesicles. The controversial experiments demonstrated that to the contrary individual protein molecules cross the relevant membranes as a result of their own motion. This was thought to be impossible at the time. Proteins Crossing Membranes is a personal narrative that tells the story of the controversy. Among other things, the author illustrates that scientists, like the rest of us, can rigidly hold onto their beliefs despite evidence that they are misguided.
Key Features
- Reviews the data in support and critical of the vesicle theory of protein secretion
- Explores the ways scientists respond to evidence that challenges a favored theory
- Documents the author’s personal experiences in this conflict-laden situation
