Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods) 1st

Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods) 1st

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by Ayman F. El-Kattan (Author),‎ Mike S. Lee (Series Editor)

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    Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods) 1st

    by Ayman F. El-Kattan (Author),‎ Mike S. Lee (Series Editor)

    Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.



    •    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability

    •    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development

    •    Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development

    •    Includes chapters about pharmacokinetic  modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)

    •    Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

     

     

    Product details

    • Series: Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
    • Hardcover: 448 pages
    • Publisher: Wiley; 1 edition (June 6, 2017)
    • Language: English
    • Format:  PDF  Original 
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